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Assistant Professor, Biology
TIRR Foundation Fellow
Jennifer Dulin, PhD: Lab Members
Areas of Interest:
Spinal cord injury
Neural stem cell transplantation
Characterizing pathophysiology of motor, sensory, and autonomic dysfunctions after SCI
Publications: 8 out of 11 peer-reviewed papers in the area of SCI (h-index: 8)
Van Niekerk, E.A., Tuszynski, M.H., Lu, P., & Dulin, J.N. (2016). Molecular and cellular mechanisms of axonal regeneration after spinal cord injury. Molecular and Cellular Proteomics, 15, 394-408.
Dulin, J.N., Karoly, E.D., Wang, Y., Strobel, H.W., & Grill, R.J. (2013). Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury. Journal of Neuroscience, 33, 652-664.
Dulin, J.N., Moore, M.L., & Grill, R.J. (2013). The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord. Journal of Neurotrauma, 30, 211-226.
Dulin, J.N., Moore, M.L., Gates, K.W., Queen, J.H., & Grill, R.J. (2011). Spinal cord injury causes sustained disruption of the blood-testis barrier in the rat. PLoS ONE, 6, e16456.
Connectivity Mapping of Neural Stem Cells for Restoring Locomotor Function
Paralyzed Veterans of America 04/01/18 – 03/31/20
Major Goals: To address the gap in our current understanding of the mechanisms by which spinal cord neural stem cell grafts can promote motor functional recovery following spinal cord injury.
Total Direct Costs: $134,721
Total Indirect Costs: $10,777 (8%)
Role: PI (15% effort)
Neural Stem Cells for Mitigating Pain after Spinal Cord Injury
Craig H. Neilsen Foundation 07/31/18 – 07/30/20
Major Goals: To test the hypothesis that spinal cord neural stem cells grafted into sites of spinal cord injury will restore inhibitory inputs onto dorsal horn pain-processing neurons at and below the site of injury, thereby attenuating hyperactive nociceptive signaling.
Total Direct Costs: $271,941
Total Indirect Costs: $27,194 (10%)
Role: PI (16.67% effort)
Chemogenetic Silencing of Nociceptors to Enhance Motor and Sensory Outcomes following Spinal Cord Injury
Mission Connect/TIRR Foundation 12/01/17 – 12/31/19
Major Goals: To test the hypothesis that silencing nociceptor activity during the acute phase of spinal cord injury will (1) attenuate the development of enhanced mechanical reactivity and pain-associated behaviors, and (2) enhance recovery of motor function.
Total Direct Costs: $50,000
Total Indirect Costs: None
Role: PI (5% effort)
Craig H. Neilsen Foundation, “Corticospinal Tract Regeneration via NF-κB Inhibition”, Spinal Cord Injury Research on the Translational Spectrum (SCIRTS) Postdoctoral Fellowship, 01/01/15-12/31/16, $138,908.
NIH T32 Fellowship, “Investigating P-glycoprotein Modulation by Inflammation in Spinal Cord Injury”, 04/01/10- 03/31/11, $65,000.
Jennifer Dulin, PhD: About
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